Day-by-day stages
Day 1 — Tunis → Kairouan
176 km, about 2 h 15. Leave Tunis on the A1, then take the Kairouan road from Enfidha. In the afternoon: the Great Mosque (Uqba Mosque), the Aghlabid basins and the medina, known for its carpets and makroud pastries.
Day 2 — Kairouan → El Jem → Sfax
150 km, about 2 h 25 of driving. Stop at El Jem for the Roman amphitheatre, one of the best preserved in the world, and its mosaic museum. Overnight in Sfax, whose walled medina is one of the most authentic in the country, well off the tourist trail.
Day 3 — Sfax → Gabes → Matmata
206 km, about 2 h 55. Motorway to Gabes, whose seaside oasis is unique in the Mediterranean, then the climb to Matmata and its cave dwellings dug into the ground — including the Sidi Driss hotel, a Star Wars set.
Day 4 — Matmata → Djerba
134 km, about 2 h 35 including the crossing. Back to the coast and the Jorf–Ajim ferry to the island. Settle in Houmt Souk, whose souk and Borj el-Kebir fort are best visited late in the day.
Day 5 — Djerba
The island can be driven across in under an hour: the Ghriba synagogue, the Djerbahood murals in Erriadh, the Guellala potters and the east-coast beaches.
Why drive rather than fly
The domestic Tunis–Djerba flight takes an hour, but it skips everything that makes the centre and south-east worth seeing: three UNESCO World Heritage sites sit on or beside this route (the Tunis medina, Kairouan, El Jem). By car, no stage is longer than 3.5 hours at the wheel.
What about the way back?
Two options. Return the car on Djerba and fly home from Djerba-Zarzis airport: this works if the offer you pick allows drop-off in another area — the condition is stated on the listing before you book. Or drive back on the A1 motorway, about 526 km and 7 hours in one long day, or two days with a night in Sousse or Monastir.
When to go
Spring and autumn are ideal for this route: pleasant temperatures for sightseeing during the day. In July and August it is very hot inland (Kairouan) and in the south (Matmata): visit early in the morning and drive in the cooler hours.